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FLASH GENE
Symbol MOGS contributors: mct/npt - updated : 25-02-2016
HGNC name mannosyl-oligosaccharide glycosidase
HGNC id 24862
DNA
TYPE functioning gene
STRUCTURE 4.35 kb     4 Exon(s)
text structure exon-4 encoding for the large 64-kDa catalytic domain of the enzyme
MAPPING cloned Y linked N status provisional
Map pter - D2S1726E - D2S1691E - GCS1 - D2S1537E - D2S1577E - cen
regionally located in the PARK3 region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2910 91 837 - Hardt (2003)
5 - 2584 - 731 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Reproductivefemale systemovary  highly
 female systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • (Arg)3 within the N-terminal domain contains ER targeting information but not required absolutely for ER localization
  • HOMOLOGY
    Homologene
    FAMILY
  • glycosyl hydrolase 63 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • removing specifically distal alpha1-2 linked glucose from the Glc (3), Man (9), GlcNAc (2) precursor after its en bloc transfer from dolichyl diphosphate to a nascent polypeptide chain in the endoplasmic reticulum
  • cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor
  • first enzyme in the processing pathway of N-linked oligosaccharide
  • is involved in the trimming of N-glycans
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    first step in the N-linked oligosaccharide processing pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS