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FLASH GENE
Symbol OSMR contributors: mct - updated : 11-03-2020
HGNC name oncostatin M receptor
HGNC id 8507
DNA
TYPE functioning gene
STRUCTURE 99.72 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 5526 - 979 - 1998 9617575
12 - 2234 - 581 - 1998 9617575
7 - 1825 - 342 - 1998 9617575
7 - 1945 - 342 - 1998 9617575
18 - 5268 - 980 - 1998 9617575
18 - 5265 - 979 - 1998 9617575
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrinepancreas    
Respiratoryrespiratory tractlarynx  highly
 respiratory tracttrachea  highly
Skeletonappendicular skeletonjointsynovia  
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
cell lineage
cell lines malignant ovarian epithelial cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four extracellular fibronectin type III-like (FNIII) domains, regions critical for receptor dimerization and function
  • a WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding
  • a box 1 motif is required for JAK interaction and/or activation
  • HOMOLOGY
    Homologene
    FAMILY IL6 family of cytokines
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • play a role in signal transduction (Scotto 2008)
  • OSMR may act as a tumour suppressor in colorectal carcinoma and OSMR methylation may play an important role in non-invasive colorectal cancer
  • adipocyte OSM&
  • 8315;OSMR signaling plays a role in adipose tissue CXCL12 production and may mitigate its effects on adipose tissue homeostasis
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of OSM receptor complex (a heterodimer of GP130 or IL6ST and OSMR)
  • part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases (Jaks) and transcription factors of the signal transducers and activators of transcription (STAT) family
  • OSM and interleukin-31 (IL31) are two cytokines belonging to the IL6 family which share a common signaling receptor subunit, OSMR
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OSM is neuroprotective by recruiting OSMR in the setting of ischemic stroke
  • SMARCA4 and STAT3 coordinately regulate gene clustering and up-regulate GFAP and OSMR transcription
  • OSMR activates a non-redundant signaling pathway by recruitment of the adapter SHC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FPLCA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    silencing inhibits the activation of the JAK/STAT3 signaling pathway, thereby suppressing the development of chronic autoimmune urticaria (CAU)
    tumoral     --over  
    in advanced cervical squamous cell carcinoma (SCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a biomarker candidate gene to predict prognosis of bladder cancer
  • Therapy target
    ANIMAL & CELL MODELS
  • mice, lacking the OSM receptor (Osmr) in adipocytes (OsmrFKO mice), exhibit derangements in adipose tissue, insulin sensitivity, and immune cell balance