Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EXOSC2 contributors: mct - updated : 03-07-2013
HGNC name exosome component 2
HGNC id 17097
DNA
TYPE functioning gene
SPECIAL FEATURE gene in gene
STRUCTURE 11.29 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2194 - 293 - 2010 20488184
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Epithelialbarrier liningepidermis  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentcornified cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
one S1 motif domain
HOMOLOGY
Homologene
FAMILY
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleolus
basic FUNCTION
  • required for a 3-prime to 5-prime exonuclease activity that generates the 3-prime end of the 5.8S rRNA
  • protein complex with ribonuclease activity
  • part of archaeal exosome, an RNA-processing protein complex
  • RNA with an A-poor 3 prime-end is degraded with higher efficiency by the EXOSC1-exosome, while the EXOSC2-exosome strongly prefers poly(A)-RNA
  • RNA with an A-poor 3 prime-end is degraded with higher efficiency by the EXOSC1-exosome, while the EXOSC2-exosome strongly prefers poly(A)-RNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mRNA decay complex (LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CCRN4L, UPF1, UPF2, UPF3B)
  • trimer of EXOSC1 or EXOSC2 subunits forms a multidomain macromolecular interaction surface on the RNase-PH domain ring with central S1 domains and peripheral KH and zinc-ribbon domains
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS