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FLASH GENE
Symbol IL31RA contributors: npt/SGE - updated : 06-04-2010
HGNC name interleukin 31 receptor A
HGNC id 18969
DNA
TYPE functioning gene
STRUCTURE 65.65 kb     15 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2393 - 764 - Ghilardi (2002)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   lowly
Nervousbrain   lowly
Reproductivefemale systemovary  lowly
 female systemplacenta  lowly
 male systemtestis  lowly
 male systemprostate  lowly
Respiratoryrespiratory tracttrachea  lowly
Skin/Tegumentskin   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticgranulocyte
Blood/Hematopoieticmonocyte
Lymphoid/Immunedendritic cell
cell lineage
cell lines constitutively expressed in epithelial cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five fibronectin type III domains
  • conjugated GlycoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 2 subfamily
  • CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • signaling receptor chain potentially involved in the development and function of monocytes and macrophages
  • strong activator of STAT3 and STAT5
  • in the heterodimeric configuration, activating MAPK3 and MAPK1 (Dreuw 2004)
  • may function in skin immunity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming an heterodimeric receptor with OSMR for IL31 signals
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with JAK1, STAT3
  • cell & other
    REGULATION
    induced by IFNG in activated monocytes
    LPS
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    up-regulated in lesional keratinocytes of patients with atopic dermatitis
    Susceptibility
    Variant & Polymorphism other
  • a C15C2C>T mutation leading to missense mutation is associated with a case of familial primary cutaneous amyloidosis (Lin 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS