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FLASH GENE
Symbol XRN1 contributors: mct - updated : 23-05-2019
HGNC name 5'-3' exoribonuclease 1
HGNC id 30654
DNA
TYPE functioning gene
STRUCTURE 141.46 kb     42 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
42 - 10143 - 1706 - 2018 29100804
41 - 10107 - 1694 - 2018 29100804
12 - 2152 - 459 - 2018 29100804
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
 pancreas exocrine   moderately
 pharynx   moderately
Endocrineadrenal gland   moderately
 thyroid   highly
Lymphoid/Immunelymph node   moderately
 thymus   moderately
Reproductivefemale systembreastmammary gland predominantly
Urinarybladder   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Xrn1 (89pc)
homolog to Pacman, the Drosophila homologue of XRN1
Homologene
FAMILY
  • 5'-3'exonuclease family
  • CATEGORY enzyme , regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in homologous recombination, meiosis, telomere maintenance, and microtubule assembly
  • acting as a microtubule-associated protein which interacts with cytoplasmic microtubules through beta-tubulin
  • acting as major 5'-3' exoribonuclease involved in mRNA decay
  • required for the 5'-3'processing of the G4 tetraplex-containing DNA and RNA substrates
  • is a key component in the 5'-3' RNA degradation pathway
  • involved in RNA interference and degradation of microRNAs as well as RNA turnover
  • role for XRN1 in decapping
  • the buffering is rapidly established when mRNA synthesis is impaired, but is delayed when mRNA degradation is impaired, apparently due to XRN1-dependent transcription repressor induction
  • is a cellular factor regulating dsRNA accumulation and dsRNA-responsive innate immune effectors
  • DIS3L2 and XRN1 affect important cellular processes such as proliferation and apoptosis
  • is a key enzyme in the control of Flavivirus and Hepatitis C viral infection also present an opportunity for the development of broad-spectrum antiviral treatments
  • is necessary for checkpoint activation upon telomere uncapping because it promotes the generation of single-stranded DNA
  • is necessary for checkpoint activation upon telomere uncapping because it promotes the generation of single-stranded DNA
  • may act as a tumor suppressor protein in osteogenic sarcoma
  • regulates gene expression in eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay
  • XRN1-dependence for translation is linked to poor structural RNA contexts for translation initiation, is mediated by interactions with components of the translation initiation machinery and correlates with an XRN1-dependence for mRNA localization at the endoplasmic reticulum
  • CELLULAR PROCESS nucleotide, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mRNA decay complex (LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CCRN4L, UPF1, UPF2, UPF3B)
  • INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
  • XRN1 directly interacts with EDC4 and ACE
  • DCPS in conjunction with XRN1 has the potential to regulate RNA stability in a transcript-selective manner in mammalian cells
  • cell & other
    REGULATION
    induced by GDNF
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    osteogenic sarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS