basic FUNCTION
| involved in homologous recombination, meiosis, telomere maintenance, and microtubule assembly |
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acting as a microtubule-associated protein which interacts with cytoplasmic microtubules through beta-tubulin |
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acting as major 5'-3' exoribonuclease involved in mRNA decay |
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required for the 5'-3'processing of the G4 tetraplex-containing DNA and RNA substrates |
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is a key component in the 5'-3' RNA degradation pathway |
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involved in RNA interference and degradation of microRNAs as well as RNA turnover |
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role for XRN1 in decapping |
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the buffering is rapidly established when mRNA synthesis is impaired, but is delayed when mRNA degradation is impaired, apparently due to XRN1-dependent transcription repressor induction |
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is a cellular factor regulating dsRNA accumulation and dsRNA-responsive innate immune effectors |
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DIS3L2 and XRN1 affect important cellular processes such as proliferation and apoptosis |
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is a key enzyme in the control of Flavivirus and Hepatitis C viral infection also present an opportunity for the development of broad-spectrum antiviral treatments |
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is necessary for checkpoint activation upon telomere uncapping because it promotes the generation of single-stranded DNA |
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is necessary for checkpoint activation upon telomere uncapping because it promotes the generation of single-stranded DNA |
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may act as a tumor suppressor protein in osteogenic sarcoma |
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regulates gene expression in eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay |
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XRN1-dependence for translation is linked to poor structural RNA contexts for translation initiation, is mediated by interactions with components of the translation initiation machinery and correlates with an XRN1-dependence for mRNA localization at the endoplasmic reticulum |