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FLASH GENE
Symbol ARHGAP24 contributors: mct - updated : 28-04-2015
HGNC name Rho GTPase activating protein 24
HGNC id 25361
DNA
TYPE functioning gene
STRUCTURE 854.93 kb     8 Exon(s)
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4644 - 748 - 2009 19144823
8 - 4195 - 653 - 2009 19144823
8 - 4010 - 663 - 2009 19144823
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin homology domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • Rac-specific Rho GTPase-activating protein that is recruited to plasma membranes by binding to activated ARF6
  • basic FUNCTION
  • mediator of the well-established antagonism of RAC1 by RHOA that suppresses leading edge protrusion and promotes cell retraction to achieve cellular polarity
  • plays a role in protecting cells against force-induced apoptosis, and this function is mediated by FLNA
  • Rac GTPase-activating protein (GAP), that is a mediator of RHO/ROCK-dependent amoeboid movement of carcinoma cells
  • ARHGAP24 and its close relatives are key regulators that promote the reciprocal inhibitory relationship between RHOA and RAC1 in cell shape changes and the mesenchymal-amoeboid transition in tumour cells
  • may function as a mediator of the regulation of RAC1 by ARF6
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is an FLNA-binding GTPase-activating protein specific for RAC1
  • is a GAP for RAC1 and a binding partner of FLNA (filamin A), a widely expressed F-actin (filamentous actin)-cross-linking protein that binds many different proteins that are important in cell regulation
  • binds to ARF6 through its pleckstrin homology domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS