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FLASH GENE
Symbol ARHGAP20 contributors: - updated : 28-09-2005
HGNC name Rho GTPase activating protein 20
HGNC id 18357
DNA
TYPE functioning gene
STRUCTURE 135.00 kb     17 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
LOC260340 11q23.1 processed pseudogene mtTFA 2 LOC390249 11 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) LOC390250 11 similar to RPB5_Human KIAA1726 11q23.1 KIAA1726 protein RDX 11q22.3-q23.1 radixin FDX1 11q22.3-q23.1 ferredoxin 1 ARHGAP20 11q23.2 Rho GTPase activating protein 20 LOC120364 11q23.2 similar to Hnrpa1 protein MGC50104 11q23.2 Similar to RIKEN cDNA 1810046K07 gene LOC120376 11q23.2 hypothetical protein LOC120376 POU2AF1 11q23.1 POU domain, class 2, associating factor 1 BTG4 11q23.2-q23.3 B-cell translocation gene 4 LOC387807 11 hypothetical gene supported by AK128145; BC039505 LOC143903 11q23.2 layilin SIK2 11q23.2 salt-inducible serine/threonine kinase 2 PPP2R1B 11q23 protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform DIBD1 11q23 disrupted in bipolar affective disorder 1 C11orf1 11p15.5 chromosome 11 open reading frame 1 CRYAB 11q22.3-q23.1 crystallin, alpha B HSPB2 11q22.3-q23.1 heat shock 27kDa protein 2 MGC14839 11q23.2 similar to RIKEN cDNA 2310030G06 gene DIXDC1  DIX domain containing 1 LOC387808 11 similar to KIAA1735 protein DLAT 11q23.1 dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) LOC246731 11q23 peptidyl prolyl isomerase H (cyclophilin H) pseudogene
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
 plexus choroid    
Reproductivefemale systemovary   
 male systemtestis   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RA (RasGTP-binding) domain (codon 198-274)
  • a RhoGAP domain (codon 363-546)
  • and two Annexin-like (ANXL) repeats (codon 657-767 and 796-909)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be involved in rearrangements of the cytoskeleton and cell signaling events that occur during spermatogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion   loss of function
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS