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FLASH GENE
Symbol PSRC1 contributors: mct/npt - updated : 01-12-2009
HGNC name proline/serine-rich coiled-coil 1
HGNC id 24472
DNA
TYPE functioning gene
STRUCTURE 3.59 kb     8 Exon(s)
regulatory sequence Promoter
Binding site
text structure promoter containing the putative p53 binding motif was responsible for p53-mediated repression
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1621 - 310 - Lo, Hsieh (2008)
8 - 1722 - 333 - Lo, Hsieh (2008)
7 - 1828 - 363 - Hsieh (2008)
8 - 1738 - 333 - Hsieh (2008)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 tonsils   highly
Nervousbrainbasal nucleicorpus callosum highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text thymus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Ser- and Pro-rich domains
  • a coiled-coil domain
  • three PXXP motifs
  • HOMOLOGY
    interspecies ortholog to murine Dda3
    Homologene
    FAMILY
    CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text localized at kinetochores
    basic FUNCTION
  • proline-rich protein that may participate in TP53-mediated growth suppression
  • microtubules-destabilizing protein that controls spindle dynamics and mitotic progression by regulating microtubules depolymerases
  • potential role in cholesterol metabolism and coronary risk
  • regulator of spindle dynamics that is essential for mitotic progression
  • TP53 and DNA-damage down-regulated gene
  • regulates spindle microtubule (MT) dynamics and chromosome movement in mitosis through its interaction with and subsequent recruitment of KIF2A
  • may be potentially involved in CENPE gliding function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with KIF2C
  • cell & other
    REGULATION
    Other regulated by TP53
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    lung cancer
    constitutional     --low  
    during DNA damage
    tumoral     --over  
    frequently in malignant peripheral nerve sheath tumor cells
    constitutional     --low  
    causes a hyper-stabilization of spindle MT, a loss of inter-kinetochore tension, and a defect in chromosome congression, leading to unaligned chromosomes at metaphase
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS