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FLASH GENE
Symbol GATAD2B contributors: mct - updated : 22-11-2014
HGNC name GATA zinc finger domain containing 2B
HGNC id 30778
DNA
TYPE functioning gene
STRUCTURE 23.63 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 7480 - 593 - 2002 1218346
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus    
Visualeyeretina   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to Drosophila simjang (simj)
intraspecies homolog to MECP1
Homologene
FAMILY P66 gene family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
basic FUNCTION
  • involved in methylation dependent transcriptional repression
  • involved in chromatin modification and regulation of transcription
  • is potentially required directly in neurones for normal cognitive performance and synapse development
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the MECP1-Mi-2/nucleosome remodelling and deacetylase complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MBD3
  • GATAD2A, GATAD2B interact with MBD2 functionally and biochemically
  • LOX catalytic domain interacting with the transcription repressor GATAD2B
  • SUFU recruits GATAD2B to block GLI-mediated HH target gene expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRD18
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS