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FLASH GENE
Symbol COMMD5 contributors: - updated : 14-02-2007
HGNC name COMM domain containing 5
HGNC id 17902
DNA
TYPE functioning gene
STRUCTURE 15.00 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1475 25 224 - Burstein
- - 1320 25 224 - Burstein
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 stomach    
Endocrineadrenal gland    
Lymphoid/Immunelymph node   highly
Skin/Tegumentskin   highly
Urinarykidneytubule   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a mutated calcium-binding site (EF-hand motif)
  • four putative "leucine zipper" motifs
  • a nuclear receptor-binding domain
  • COMM (copper metabolism gene MURR1) domain
  • HOMOLOGY
    Homologene
    FAMILY MURR1/COMMD1 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • suppressing NF-kappaB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+ regulated
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS