basic FUNCTION
| acting as a coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D |
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being necessary for signaling by class 3 semaphorins and subsequent remodelling of the cytoskeleton |
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playing a role in axon guidance, invasive growth and cell migration |
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modulating the affinity of a complex composed of a neuropilin and a plexin for specific semaphorins |
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implicated in dendritic cell function in the immune system |
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proprioceptive sensory axon-specific receptor for SEMA6C and SEMA6D, which are expressed in a dynamic pattern in the dorsal horn of spinal cord |
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role for PLXNA1-mediated axonal exclusion in organizing the projection pattern of spinal sensory afferents |
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may play an important role in the occurrence and development of gastric carcinoma, and be related to tumor angiogenesis and proliferation |
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principal receptor component for class III and class VI semaphorins, and crucially involved in the entry of dendritic cells (DCs) into the lymphatics |
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required for neural crest migration and suggest that it may cooperate with PTK7 to affect neural crest migration |
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PLXNA1, PLXNA4 are required simultaneously for transduction of inhibitory SEMA3A signals and that they form complexes |
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requirement for NRP1 and PLXNA1 in dendrite polarization occurs at a developmental time point after the cells have already extended their basally directed axon |
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is a neuronal receptor protein that facilitates axon guidance during embryogenesis |
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likely crucial involvement of PLXNA1 in the midline crossing of callosal axons during CC development |