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FLASH GENE
Symbol SLC25A26 contributors: mct - updated : 09-12-2015
HGNC name solute carrier family 25, member 26
HGNC id 20661
DNA
TYPE functioning gene
STRUCTURE 246.41 kb     8 Exon(s)
MAPPING cloned Y linked N status confirmed
Physical map
NPCR 3p21.1 nasopharyngeal carcinoma-related protein LOC131691 3p21.1 similar to peptidyl-Pro cis trans isomerase LOC391540 3 similar to coated vesicle membrane protein LOC391541 3 similar to peptidyl-Pro cis trans isomerase PTPRG 3p14.2 protein tyrosine phosphatase, receptor type, G HT021 3p21.1 HT021 FEZL 3p21.1 likely ortholog of mouse and zebrafish forebrain embryonic zinc finger-like CADPS 3p21.1-p14.3 Ca2+-dependent activator protein for secretion LOC389127 3 similar to 40S ribosomal protein S10 LOC132205 3p21.1 similar to keratin 8, type II cytoskeletal - human SYNPR 3p14.3 synaptoporin LOC132203 3p21.1 similar to hypothetical protein A430083B19 LOC391542 3 similar to hypothetical protein FLJ23834 LOC132200 3p21.1 hypothetical protein BC015210 NIF3L1BP1 3p21.1 Ngg1 interacting factor 3 like 1 binding protein 1 SCA7 3p13-p12 spinocerebellar ataxia 7 (olivopontocerebellar atrophy with retinal degeneration) p44S10 3p21.1 proteasome regulatory particle subunit p44S10 PRICKLE2 3p21.1 prickle-like 2 (Drosophila) ADAMTS9 3p14.3-p14.2 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9 BAIAP1 3p14.1 BAI1-associated protein 1 SLC25A26 3p14.3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 26 LRIG1 3p14 leucine-rich repeats and immunoglobulin-like domains 1 TA-KRP 3p14 T-cell activation kelch repeat protein SUCLG2 3p14.3 succinate-CoA ligase, GDP-forming, beta subunit LOC375350 3p14.3 COP9 pseudogene LOC151645 3p14.3 protease (prosome, macropain) 26S subunit, ATPase, 1 pseudogene FLJ25161 3p14.3-p14.2 hypothetical protein FLJ25161 LOC152122 3p14.2 hypothetical LOC152122 MGC34132 3p14.2 hypothetical protein MGC34132 TMF1 3p21-p12 TATA element modulatory factor 1 UBE1C 3p24.3-p13 ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) JWA 3p14 ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) LMOD3 3p14.1 leiomodin 3 (fetal) GRSP1 3p14.2 leiomodin 3 (fetal) MITF 3p14.1-p12.3 microphthalmia-associated transcription factor LOC391543 3 similar to KIAA1839 protein FOXP1 3p14.1 forkhead box P1 LOC391544 3 similar to MGC39820 protein GPR27 3p21-p14 G protein-coupled receptor 27 PROK2 3p21.1 prokineticin 2 RYBP 3p13 RING1 and YY1 binding protein LOC339875 3p14.2 hypothetical LOC339875
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2686 29.3 274 - 2004 14674884
9 - 2154 - 186 - 2004 14674884
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Endocrineneuroendocrinepituitary  moderately
Hearing/Equilibriumear   highly
Lymphoid/Immunetonsils   moderately
Nervousbrain   lowly
Reproductivefemale systemplacenta  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal moderately
cell lineage
cell lines
fluid/secretion highly in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four ef-hand calcium-binding domains
  • three solcar repeats
  • HOMOLOGY
    interspecies homolog to rattus Slc25a26 (88.1 pc)
    homolog to murine Slc25a26 (88.3 pc)
    Homologene
    FAMILY
  • mitochondrial carrier family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    text
  • multi-pass membrane protein
  • transported into the mitochondria where it is converted into S-adenosylhomocysteine in methylation reactions of DNA, RNA and proteins
  • basic FUNCTION
  • mediatings the transport of S-adenosylmethionine (SAM) into the mitochondria
  • acting as a calcium-dependent mitochondrial aspartate and glutamate carrier
  • may have a function in the urea cycle
  • physiological role of SAMC is probably to exchange cytosolic SAM for mitochondrial S-adenosylhomocysteine
  • synthesized by methionine adenosyltransferase from methionine and ATP in the cytoplasm and subsequently distributed throughout the different cellular compartments, including mitochondria, where methylation is mostly required for nucleic-acid modifications and respiratory-chain function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ca2+
    protein
  • mitochondrial SLC25A26 targets, ANT1 and ANT2, and the electron-transferring flavoprotein ETFB
  • cell & other
    REGULATION
    inhibited by tannic acid and Bromocresol Purple
    ASSOCIATED DISORDERS
    corresponding disease(s) SAMD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS