basic FUNCTION
| acting as a soluble osteoblast regulator |
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skeletal muscle-derived secretory factor playing a physiological in glucose metabolism |
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plays a role in the resistance of fast-glycolytic myofibers to the insulin-stimulated glucose uptake |
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playing a role as a specific NPR3 ligand capable of modulating local levels of C natriuretic peptide and its effects on skeletal development |
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naturally occurring ligand of the NPR3 clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR3, thus locally elevating levels of C-type natriuretic peptide (Moffatt 2007) |
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musclin is involved in hypertension |
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enhances physical endurance by promoting mitochondrial biogenesis |
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is a muscle-secreted cytokine that disrupts glucose uptake and glycogen synthesis in type 2 diabetes |
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acts as a novel exercise-responsive myokine and is implicated in various cardiac diseases |
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OSTN protects against diabetic cardiomyopathy (DCM) via restoring PRKG1-dependent proteasomal activity |
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periosteal-osteoblast-derived secretory peptide, Osteocrin (OSTN), is a mechanotransducer involved in load-induced long bone growth |
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crucial role of OSTN as a mechanotransducer converting mechanical loading to NPPC-dependent bone formation |
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OSTN enhances the abundance of C-type natriuretic peptide (NPPC), thereby promoting cardiomyocyte contractility through protein kinase A and inhibiting fibroblast activation through protein kinase G signaling |
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is likely a negative regulator of adipose thermogenesis |