Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | SLC5A1 | contributors: mct - updated : 17-01-2019 |
HGNC name | solute carrier family 5 (sodium/glucose cotransporter), member 1 |
HGNC id | 11036 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 70.00 kb 15 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
---|
MAPPING | cloned | Y | linked | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
---|
|
EXPRESSION |
Type |
tissue |
|
cells |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| |
|
HOMOLOGY |
interspecies | homolog to murine Slc5a1 |
Homologene |
FAMILY |
CATEGORY | transport carrier |
SUBCELLULAR LOCALIZATION | plasma membrane |
basic FUNCTION | |
| |
| |
| |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | active transport |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
| |
| |
|
cell & other |
REGULATION |
activated by | JAK2 (upregulates SLC5A1 activity which may play a role in the effect of JAK2 during ischemia and malignancy) | |
HPV18 E6 oncoprotein that participates in the upregulation of SLC5A1 | ||
BRAF, that upregulates SLC5A1 activity, an effect requiring vesicle insertion into the cell membrane |
Other | regulated by luminal monosaccharides |
regulation by AMP-activated protein kinase PRKAB1 | |
its expression and/or function are regulated by insulin and leptin, and are perturbed in disease |
ASSOCIATED DISORDERS |
corresponding disease(s) | GGM |
Susceptibility |
Variant & Polymorphism
| |
Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |