playing a role in adaptation to hypoxia and may be related to cellular oxygen sensing
may be involved in the degradation of hypoxia-inducible transcription factors under normoxia
catalyze the formation of 4-hydroxyproline in -X-Pro-Gly-sequences and have an essential role in collagen synthesis
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
ADM up-regulated the mRNA and protein expressions of HIF1A- and HIF1-targeted genes, and ADM up-regulated the protein expressions of HIF1A through down-regulation of PH4TM mRNA expression and P4HTM activity
P4HTM overexpression in tumor cells stimulated the expression of TGFA, which was necessary and sufficient to promote angiogenic sprouting of endothelial cells