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FLASH GENE
Symbol CDHR2 contributors: npt/ - updated : 23-02-2006
HGNC name cadherin-related family member 2
HGNC id 18231
DNA
TYPE functioning gene
STRUCTURE 46.41 kb     32 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
32 - 4127 141 1310 - -
- - 4313 141 1310 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestine   
 liver    
 mouth    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • nine cadherin repeat domains
  • a unique cytoplasmic region
  • HOMOLOGY
    interspecies ortholog to murine BC040758
    Homologene
    FAMILY
  • cadherin superfamily
  • protocadherin family
  • CATEGORY adhesion , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • putative molecular switch for contact inhibition of epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • PDZ protein
  • MAST2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in kidney, colon and liver cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS