basic FUNCTION
| apoptotic activator |
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key molecule for HDAC inhibitors (FK228 and CBHA)-mediated enhancing effect on ionizing radiation-induced cell death |
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plays a critical role in apoptosis signaling and can function as a tumor suppressor |
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required for death-receptor-induced necroptosis |
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novel component of the TP53-independent tumor suppressor pathway triggered by MYC |
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can act as a sentinel for stress-impaired CAP-dependent protein translation machinery |
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sentinel considered to register damage at the cytoskeleton and to convey a death signal to B-cell lymphoma 2 (BCL2) |
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induced in human IEC (intestinal epithelial cell) by the loss of cell attachment and is likely to play an important role in the regulation of IEC survival |
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may be critical for epithelial cell homeostasis |