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FLASH GENE
Symbol AGGF1 contributors: SGE/npt - updated : 09-10-2009
HGNC name angiogenic factor with G patch and FHA domains 1
HGNC id 24684
DNA
TYPE functioning gene
STRUCTURE 34.80 kb     14 Exon(s)
regulatory sequence Promoter
Binding site   silencer   transcription factor
text structure
  • two repressor sites (-1971 to -3990 and -7521 to -8391) (Fan 2009)
  • two activator sites (a GATA1 binding site in -295 to -300, -125 to -159) (Fan 2009)
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 4480 - 714 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Epithelialbarrier/liningendothelium  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    Skeletonosteoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one G-patch domain
  • one FHA domain
  • HOMOLOGY
    interspecies homolog to murine Aggf1 (78.7pc)
    homolog to rattus Aggf1 (76.6pc)
    Homologene
    FAMILY
    CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • cytoplasmic in microvascular endothelial cells
  • secreted when endothelial cell tube formation is initiated upon angiogenesis
  • basic FUNCTION
  • acting as a potent angiogenic factor
  • can bind to endothelial cells and promote cell proliferation
  • may act in an autocrine fashion
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • two-component sensor molecule activity
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
  • interacting with secreted angiogenic factor TNFSF12
  • cell & other
    REGULATION
    induced by GATA1 binding on its activator site (Fan 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s) KTWS1
    Susceptibility Klippel-Trenaunay syndrome (KTS)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS