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FLASH GENE

Symbol

MRPL11

contributors: - updated : 14-02-2004

HGNC name	mitochondrial ribosomal protein L11
HGNC id	14042

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	2.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 840 isoform a - 192 - - variant 2 - splicing 762 isoform b - 168 - - lacking an internal segmant variant 3 - splicing 934 isoform c - 181 - - an additional segment, C terminal region distinct from isoform a

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to E Coli (50S), Drosophila, C Elegans, S Cerevisiae mitochondrial ribosomal protein

Homologene

FAMILY

CATEGORY

structural protein , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
text	mitochondrial ribosome

basic FUNCTION	mitochondrial proteins biosynthesis
	ribosomal structure and biogenesis

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the large subunit (39S) of the mitochondrial ribosome, including two RNA molecules and, at least, 70 MRPs among which 47 proteins for the large subunit

INTERACTION

DNA

RNA

mRNAs

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS