SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,chromatin/chromosome,kinetochore
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text
| primarily to the spindle pole body (spb) and to a lesser extent along spindle microtubules |
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localizes to the centrosome |
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localization at the microtubule plus end and centrosomes, and kinetochores |
basic FUNCTION
| may be playing a role in the attachment, organization, and/or dynamics of microtubule ends at the spindle pole body |
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mediating the association of hnRNP A2-positive granules with microtubules during transport and/or localization |
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plays a major role in organizing spindle poles, whereas its role in stabilizing spindle microtubules is minor and, at least in part, mediated via interaction with TACC3 |
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processive polymerase that catalyzes numerous rounds of tubulin subunit addition while at the microtubule end and argue against the tubulin shuttle model |
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displays an elevated expression pattern in tumor cells, and is thought to enhance microtubule polymerization and nucleation |
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microtubule-associated protein that binds to heterogeneous nuclear ribonucleoprotein (hnRNP) A2 |
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is necessary for myelin basic protein expression in oligodendrocytes |
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ensures spindle bipolarity by counteracting the activity of the microtubule-depolymerizing kinesin KIF2C |
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protects kinetochore microtubules from depolymerization by KIF2C and plays an essential role in centrosomal microtubule assembly, a function independent of KIF2C activity |
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potentially required for chromosome motility as a downstream consequence of reduced microtubule dynamics and/or density |
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is a microtubule plus-end binding protein that alters microtubule dynamics by promoting microtubule growth |
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a TACC3/CKAP5/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging |
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MAPRE1 and microtubule polymerase CKAP5-act together to strongly promote microtubule growth to cellular rates |
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is one of several proteins capable of coupling to the microtubule ends under load |
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dynamically links to the ends of growing and shrinking microtubules |
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accelerates microtubule growth, and it retains its polymerase activity when coupled to a bead |
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complementary activities of TPX2 and CKAP5 constitute an efficient importin-regulated microtubule nucleation module |
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CKAP5 is likely important in oocyte maturation and early embryo development, and CKAP5 might work together with CLTC in oocyte maturation |