Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

KCTD10

contributors: SGE/npt - updated : 12-07-2013

HGNC name	potassium channel tetramerisation domain containing 10
HGNC id	23236

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	28.70 kb     7 Exon(s)

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF
	Binding site   enhancer   silencer
text structure	a CpG island near to the transcription start site in the promoter (Liu 2009)
	a SP1 and AP2 binding sites (Liu 2009)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_031954 7 - 4057 NP_114160 - 313 - Zhou (2005)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessels aorta       Digestive esophagus       highly   mouth       highly Respiratory respiratory tract trachea     highly Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one BTB (POZ) domain

conjugated

PhosphoP

mono polymer

heteromer , tetramer

HOMOLOGY

interspecies

homolog to murine Kctd10 (98.4pc)

intraspecies

homolog to PDIP1

Homologene

FAMILY	polymerase delta-interacting protein 1 (PDIP1) gene family
	KCTD10/KCTD13/TNFAIP1 family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	K+ channel activity
	may be associated with DNA synthesis and cell proliferation (Wang 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	potassium ion transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	can interact with the small subunit of DNA polymerase delta and PCNA (Wang 2009)
	TNFAIP1 overexpression resulted in ubiquitin-mediated degradation of KCTD10 proteins

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism other	KCTD10 (V206VT->C and i5642G->C) variants may contribute to the variation in HDL-cholesterol concentrations, particularly in subjects with high carbohydrate intakes (Junyent 2009)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS