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FLASH GENE
Symbol HTR2A contributors: mct/ - updated : 11-02-2013
HGNC name 5-hydroxytryptamine (serotonin) receptor 2A
HGNC id 5293
DNA
TYPE functioning gene
STRUCTURE 63.48 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map cen - D13S21 - ESD ,HTR2A - RB1 - D13S25 - qter
Text see RB1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 3564 - 471 - 1998 9729300
3 - 2824 - 387 - 1998 9729300
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex predominantly Homo sapiensAdult
 brainhindbraincerebellum moderately Homo sapiensAdult
Reproductivemale systemtestis  lowly
Visualeye   lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervouspyramidal cell Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
IMPRINTING paternally
text paternally imprinted in some individuals (polymorphic imprinting)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a seven transmembrane segments (7TM_1) receptor
  • a PDZ domain-binding motif
  • HOMOLOGY
    interspecies homolog to rattus Htr2a (91.30 pc)
    homolog to murine Htr2a (91.51 pc)
    Homologene
    FAMILY
  • G-protein coupled receptor superfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • 5-hydroxytryptamine (serotonin) receptor, subtype 2A activating the phosphatidylinositol cycle
  • rapid modulation of spine morphology by HTR2A through kalirin-7 signaling
  • participates in diverse psychiatric disorders by regulating the activity of serotonin
  • participates in human spatial cognitive abilities and spatial working memory
  • undergoes constitutive and agonist-dependent internalization
  • involved in tracheal smooth muscle contraction, bronchoconstriction and control of aldosterone production
  • GRM2 and HTR2A form a functional heteromeric complex through which hallucinogenic drugs cross-signal to the Gi-coupled receptor
  • its activation upregulates the function of the neuronal K-Cl cotransporter SLC12A5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • HTR2A/GRM2 complex integrates serotonin and glutamate signaling to regulate the sensory gating functions of the cortex, a process that is disrupted in psychosis
  • HTR2A/GRM2 complex is necessary for the neuropsychological responses induced by hallucinogens 8)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • INADL
  • CASK
  • APBA1
  • DLG1
  • DLG4
  • target of several hallucinogens, antipsychotics, anxiolytics, and antidepressants
  • interacting with CBL (C-terminal region plays a crucial role in the temporal and spatial control of HTR2A recycling)
  • heteromeric complex between the HTR2A and GRM2, integrates ligand input, modulating signaling output and behavioral changes
  • HTR2A, HTR2B, HTR2C are implicated as being critical for induction of PTHLH and RUNX2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in brain from untreated schizophrenic subjects
    constitutional     --over  
    significantly higher level of HTR2A mRNA in platelets of patients with autistic spectrum disorders
    Susceptibility
  • to schizophrenia
  • to autism, bipolar 1 disorder
  • to panic disorder
  • to alcohol dependence
  • Variant & Polymorphism SNP , other
  • SNP in autism and in bipolar 1 disorder
  • allele T-102 increasing thre risk of schizophrenia
  • A allele may contribute to racial differences in outcomes of antidepressant treatment
  • a potential role of the T102C HTR2A polymorphism in development of alcohol dependence
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatry  
    complex HTR2A/GRM2 is a promising new target for the treatment of psychosis
    ANIMAL & CELL MODELS