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FLASH GENE
Symbol EXOC6 contributors: mct - updated : 29-06-2016
HGNC name exocyst complex component 6
HGNC id 23196
DNA
TYPE functioning gene
STRUCTURE 232.66 kb     23 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 3696 - 799 - 2004 15292201
23 - 3762 - 820 - 2004 15292201
22 - 3650 - 804 - 2004 15292201
22 - 3647 - 803 - 2004 15292201
18 - 3341 - 701 - 2004 15292201
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Sec15
Homologene
FAMILY SEC15 family
CATEGORY transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule
intracellular,cytoplasm,cytoskeleton,intermed filament
text EXOC6 co-localizes with RAB8A in primary cilia
basic FUNCTION
  • may be implicated in vesicle docking during exocytosis
  • its overexpression affects vesicular trafficking from the recycling endosomes and blocks the formation of primary cilia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component similar to a component of the multiprotein complex required for exocytosis in yeast
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • exocyst component EXOC6 directly interacts with RAB8A in its activated conformation
  • binding of EXOC6 to both RAB11A and RAB8A serves to coordinate vesicle budding from the recycling endosomes and vesicle tethering at the plasma membrane
  • STK38L-mediated RAB8A phosphorylation is crucial for ciliogenesis by triggering the switch in binding specificity of RAB8A from phosphatidylserine (PS) to EXOC6, thereby promoting local activation of RAB8A and ciliary membrane formation
  • association of RAB10-GTP with EXOC6/6B is a molecular link between insulin signaling and the exocytic machinery in SLC2A4 translocation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    affects endosomal trafficking and blocks ciliogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS