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FLASH GENE
Symbol PPIL1 contributors: mct - updated : 06-10-2006
HGNC name peptidylprolyl isomerase (cyclophilin)-like 1
HGNC id 9260
DNA
TYPE functioning gene
STRUCTURE 20.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - D6S1875 - D6S291 /PPIL1 - D6S1832 - cen
Authors Mann (98)
Text see OTOF
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus   highly
 stomach   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PPIase cyclophilin-type domain
  • HOMOLOGY
    Homologene
    FAMILY
  • immunophilin class M family
  • cyclophilin family of peptidylprolyl isomerases (PPIases)
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • peptidylprolyl isomerase (cyclophilin)-like 1, cellular target of cyclosporin A
  • could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
  • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with SNW1 (recruits PPIL1 into the spliceosome by a region other than the peptidylprolyl isomerase active site)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS