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FLASH GENE
Symbol TOMM7 contributors: mct/npt - updated : 14-06-2008
HGNC name translocase of outer mitochondrial membrane 7 homolog (yeast)
HGNC id 21648
DNA
TYPE functioning gene
STRUCTURE 10.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
MAPPING cloned Y linked N status provisional
Physical map
LOC389470 7 LOC389470 IL6 7p21 interleukin 6 (interferon, beta 2) SLC13A1 7q31-q32 solute carrier family 13 (sodium/sulfate symporters), member 1 LOC256227 7p15.3 similar to Six transmembrane epithelial antigen of prostate LOC285938 7p15.3 similar to ribosomal protein S26 TOMM7 7p15.3 translocase of outer mitochondrial membrane 7 homolog (yeast) LOC221838 7p15.3 eukaryotic translation elongation factor 1 alpha 1 pseudogene LOC392872 7 similar to 60S ribosomal protein L12 DRCTNNB1A 7p15.3 similar to 60S ribosomal protein L12 IL6 7p21 interleukin 6 (interferon, beta 2) FLJ35834 7q31.33 hypothetical protein FLJ35834 SBBI26 7p15.3 SBBI26 protein LOC389472 7 similar to ribosomal protein S26 TAC1 7q21.3-q22.1 tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma) TOMM7 7p15.3 translocase of outer mitochondrial membrane 7 homolog (yeast) NDUFA5 7q31.33 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa NUPL2 7p15 nucleoporin like 2 LOC392004 7 similar to 60S ribosomal protein L12 ASB15 7q31.31 ankyrin repeat and SOCS box-containing 15 GPNMB 7p15 glycoprotein (transmembrane) nmb ASNS 7q21.3 asparagine synthetase LOC392780 7 similar to cardiac leiomodin DRCTNNB1A 7p15.3 similar to cardiac leiomodin C7orf30 7p15.3 chromosome 7 open reading frame 30 WASL 7q31.3 Wiskott-Aldrich syndrome-like IMP-3 7p11 IGF-II mRNA-binding protein 3 LOC392751 7 LOC392751 LOC286031 8p23.1 hypothetical protein LOC286031 LOC392752 7 similar to seven transmembrane helix receptor LOC392753 7 similar to olfactory receptor GA_x6K02T2PVTD-14054886-14053957 OCM 7p13-p11 oncomodulin HYAL4 7q31.3 hyaluronoglucosaminidase 4 SBBI26 7p15.3 SBBI26 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 746 6.2 55 - Johnston (2002)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Endocrineadrenal gland    
 thyroid   highly
Lymphoid/Immunetonsils   highly
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DNAPK phosphorylation site
  • two N-myristoylation motifs
  • mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
  • Tom7 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • involved in intracellular protein transport
  • may play a role in destabilizing the interactions between the TOM complex and the TOM receptor
  • required for stabilization of the TOM complex
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS cellular trafficking transport , mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component
  • small regulatory component of the translocase of the outer mitochondrial membrane
  • C9orf105 as well as TOMM7, were associated with TOMM40 in the TOM complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • complexed with TOM40 and TOM22
  • cell & other
    REGULATION
    Other levels of TOM22 in mitochondria can accelerate the rate of TOMM7 assembly into the mature TOM complex
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS