basic FUNCTION
| involved in switching a cell from p53-mediated growth arrest to apoptosis by regulating the stability of p21WAF1 through its E3 ubiquitin ligase activity (Ng 2003) |
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E3-ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation |
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inducing apoptosis via a TP53/p53-dependent but caspase-independent mechanism (Huang 2006) |
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regulating the level of BAX and protecting cell from unprompted BAX activation and cell death (Benard 2010) |