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FLASH GENE
Symbol RNF144B contributors: SGE/npt - updated : 14-05-2014
HGNC name ring finger 144B
HGNC id 21578
DNA
TYPE functioning gene
STRUCTURE 81.26 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 4782 33.7 303 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one IBR-type zinc finger
  • two RING-type zinc fingers
  • HOMOLOGY
    interspecies homolog to murine Rnf144b (88.4pc)
    homolog to rattus Rnf144b (88.4pc)
    Homologene
    FAMILY
  • RBR family
  • RNF144 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    text mostly cytosolic in healthy cells but upon induction of apoptosis, accumulating in mitochondrial domain enriched with BAX (Benard 2010)
    basic FUNCTION
  • involved in switching a cell from p53-mediated growth arrest to apoptosis by regulating the stability of p21WAF1 through its E3 ubiquitin ligase activity (Ng 2003)
  • E3-ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation
  • inducing apoptosis via a TP53/p53-dependent but caspase-independent mechanism (Huang 2006)
  • regulating the level of BAX and protecting cell from unprompted BAX activation and cell death (Benard 2010)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ions Zn2+
  • protein
  • interacting with UBE2L3, UBE2L6 and LCMT2
  • interacting with BAX (Benard 2010)
  • is a potentially critical component of epithelial homeostasis, acting downstream of TP63 to regulate cellular levels of CDKN1A and TP63
  • cell & other
    REGULATION
    induced by p53
    Other auto-ubiquitinated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS