protein
| partner of TREX1 in DNA damage checkpoint pathway |
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inhibition PLK1 activity and regulating cyclin B1 phosphorylation |
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phosphorylation of CHEK1 |
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associates with CLSPN |
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interacting with H2AFX (ATR and H2AX provide cooperative safeguards to ensure genome stability during DNA replication) |
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interacting with CDC5L |
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TIMELESS-TIPIN complex stabilizes replication forks both by preventing the accumulation of ssDNA upstream of ATR-CHEK1 function and by facilitating phosphorylation of CHEK1 by ATR |
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interaction with FANCM (FANCM is required for efficient activation of ATR by promoting TOPBP1 loading on chromatin) |
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nucleotide excision repair (NER) is regulated by the ATR/TP53 checkpoint via modulation of XPA nuclear import and this regulation occurs in a cell cycle-dependent manner |
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ATR can have a central role in inhibiting the initiation of DNA replication by the regulation of CDC6 by CDH1 |
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HORMAD2-dependent recruitment of ATR to unsynapsed chromosome axes constitutes a mechanism for the surveillance of asynapsis |
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CCAR2 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage |
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HORMAD2-dependent quality control mechanism that recognizes unsynapsis and recruits ATR activity during mammalian meiosis |
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novel control mechanism in the NER pathway by regulating the steady-state level of XPA1 through posttranslational modifications by which ATR-mediated phosphorylation induces XPA1 stabilization by antagonizing HERC2-catalyzed XPA1 ubiquitination |
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NEK1, is critical for initiating the ATR response |
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ATR functions in a complex with its regulatory partner ATRIP |
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NBN and TOPBP1 have the potential to activate ATR independently, although both are required for functional activation of ATR |
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DDB2 and XPC, two early UV damage recognition factors, are required for the damage-specific ATR and ATM recruitment and phosphorylation |
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ATR-ATRIP protein kinase complex plays a crucial role in the cellular response to replication stress and DNA damage |
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NBN-mediated mode of ATR activation is important for the repair of replication-associated DSBs |
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TICRR stimulates ATR phosphorylation of CHEK1 in a TOPBP1-dependent manner |
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ATR-FANCM feedback loop is present in the FA and replication stress response pathways and that it is required for both efficient ATR/CHEK1 checkpoint activation and FANCM function |
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phosphorylation of SMARCAL1 is one mechanism by which ATR prevents fork collapse, promotes the completion of DNA replication, and maintains genome integrity |
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catalyzes histone H2AFX phosphorylation, the epigenetic event leading to gene inactivation |
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role for ATR in the epigenetic regulation of gene expression and presents a new technique for ablating gene function in the germline |
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phosphorylation of SMARCAL1 is one mechanism by which ATR prevents fork collapse, promotes the completion of DNA replication, and maintains genome integrity |
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ATR signaling promoted the transient association of endogenous FANCD2 with the MCM2-MCM7 replicative helicase independently of FANCD2 monoubiquitination |
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HELQ is associated with the RAD51 paralogs RAD51B/C/D and XRCC2, and with the DNA damage-responsive kinase ATR |
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ATR-mediated suppression of dormant origins shields active forks against irreversible breakage via preventing exhaustion of nuclear RPA1 |
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USP20 is phosphorylated by ATR, resulting in disassociation of the E3 ubiquitin ligase HERC2 from USP20 and USP20 stabilization |
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ERH regulates the splicing of the DNA damage response proteins ATR in hepatocellular carcinoma cells |
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single-stranded DNA-binding protein complex, NABP1/NABP2-INTS3 can recruit the checkpoint complex to initiate ATR signaling |
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PIAS3 is the only member of the PIAS family that is indispensable for ATR activation |
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ETAA1 functions in parallel to the TOPBP1/RAD9/HUS1/RAD1 pathway to regulate ATR and maintain genome stability |
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TET3 is an ATR kinase target that oxidizes DNA during ATR-dependent DNA damage repair |
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TOPBP1 and ETAA1 activate ATR using similar motifs and mechanisms |
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TOPBP1 and ETAA1 dimerization is important for optimal ATR signaling and genome stability |
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SMG7 is an indispensable signaling component in the ATR-CEHK1 pathway during genotoxic stress response |