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FLASH GENE
Symbol RHEBL1 contributors: mct - updated : 19-12-2015
HGNC name Ras homolog enriched in brain like 1
HGNC id 21166
DNA
TYPE functioning gene
STRUCTURE 5.31 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1192 20.69 183 - 2005 16328882
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Lymphoid/Immunespleen   highly Homo sapiens
Nervousbrain   highly Homo sapiens
Reproductivefemale systemuterus  highly Homo sapiens
 female systemplacenta  highly Homo sapiens
 male systemtestis  highly Homo sapiens
Respiratorylung   highly Homo sapiens
Urinarybladder   highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Rhebl1
homolog to rattus Rhebl1
intraspecies paralog to RHEB
Homologene
FAMILY HEB family
CATEGORY signaling
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
text
  • RHEB and RHEBL1 localize primarily to the endoplasmic reticulum and Golgi apparatus
  • basic FUNCTION
  • mediating signal transduction
  • positive regulator of NF-kappa B-mediated gene transcription
  • cytoplasm protein but not evenly distributed in cytoplasm
  • when overexpressed in the cells
  • possible role of RHEB and RHEBL1 in regulating de novo pyrimidine nucleotide synthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • may be impacting the MTOR pathway in a different manner than RHEB
  • RHEB and RHEBL1 are unique members of the Ras superfamily and play central roles in regulating protein synthesis and cell growth by activating MTOR
  • RHEB proteins binds to CAD protein (RHEB and RHEBL1 binds CAD in a GTP- and effector domain-dependent manner)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    DHH-RHEBL1 fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3-GLIS2-positive childhood AML
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS