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FLASH GENE
Symbol TRIM60 contributors: mct - updated : 28-09-2017
HGNC name tripartite motif-containing 60
HGNC id 21162
DNA
TYPE functioning gene
STRUCTURE 9.87 kb     3 Exon(s)
text structure
  • TRIM60 and TRIM61 are intronless except for a solitary intron in the 5prime-untranslated region
  • TRIM60, TRIM61 mRNAs are apparently transcribed from the same putative promoter and may be products of alternative splicing of the same pre-mRNA generated through differential 3 prime cleavage and polyadenylation
  • MAPPING cloned Y linked N status confirmed
    Map cen - D4S1603 - TRIM60 - D4S2952 - D4S417 - qter
    Authors UCSC (2009)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1842 55 471 - 2008 18836477
    4 - 2016 - 471 - 2008 18836477
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING finger domain
  • a B box-type zinc finger
  • a coiled-coil domain
  • a B30.2/SPRY domain
  • HOMOLOGY
    interspecies homolog to murine Trim60 (54.2 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • acting as an ubiquitin protein ligase
  • TRIM60 interacts with the kinesin molecular motors possibly contributing to kinesin-dependent mobilization of specific cargo(s) along the microtubule in the testis
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • TRIM60 most likely interacted with KIF3A-KIF3B independent of the adaptor kinesin-associated protein KIFAP3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS