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FLASH GENE
Symbol TRIM68 contributors: npt - updated : 06-02-2009
HGNC name tripartite motif-containing 68
HGNC id 21161
DNA
TYPE functioning gene
STRUCTURE 9.54 kb     7 Exon(s)
MAPPING cloned Y linked N status confirmed
Map pter - TRIM68 - D11S1758 - D11S4181 - cen
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 3321 56.1 485 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemprostate   
cell lineage
cell lines many cancer cell lines, differentially expressed in androgen-dependent, androgen independent prostate cancer cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING-type zinc finger
  • a B-box type zinc finger
  • a coiled-coil domain
  • a B30.2/SPRY domain
  • HOMOLOGY
    interspecies homolog to murine Trim68 (77.9 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a role of autoantigen in systemic lupus erythematosus and primary Sjoegren syndrome (Billaut-Mulot 2001, Ozato 2008)
  • being a putative E3 ubiquitin ligase (Miyajima 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with androgen receptor (Miyajima 2008)
  • cell & other
    REGULATION
    induced by IFN-gamma and LPS
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • being a potentially therapeutic target for prostate cancer (Miyajima 2008)
  • ANIMAL & CELL MODELS