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FLASH GENE
Symbol BTLA contributors: - updated : 14-01-2004
HGNC name B and T lymphocyte associated
HGNC id 21087
DNA
TYPE functioning gene
STRUCTURE 33.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text a spliced variant lacking exon 2
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Lymphoid/Immunelymph node    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • three potential N-linked glycosylation sites
  • a variable-type Ig domain
  • a transmembrane region
  • two immunoreceptor tyrosine-based inhibitory motifs (ITIMs)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Btla
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION
    basic FUNCTION inhibits antigen-induced production of IL-2
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS