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FLASH GENE
Symbol DOK4 contributors: - updated : 16-04-2005
HGNC name docking protein 4
HGNC id 19868
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing - - - - Baldwin
  • containing a 39 amino acid insertion in the C-terminal region
  • having an enhanced inhibitory effect on signaling downstream of Fyn, Ret, and EGFR
  • - - 2727 - 326 - Cai
    N-terminus and C-terminus of DOK4 possess opposing inhibitory and stimulatory properties
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     liver   highly
    Endocrinepancreas    
    Urinarykidney   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • pleckstrin homology and PTB
  • short carboxl-terminal tail containing a few tyrosine motifs
  • HOMOLOGY
    interspecies ortholog to murine Dok4
    intraspecies homolog to DOK5
    Homologene
    FAMILY DOK family
    CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be involved in the regulation of the immune response induced by T cells
  • signaling proteins with potential roles in insulin and IGF-1 action
  • activates MAPK
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • insulin recptor binding
  • binding SH2 proteins like CRK, SRC, FYN
  • cell & other
    REGULATION
    Other tyrosine-phosphorylated in response to insulin and IGF-1
    dephosphorylated by a pervanate-inhibitable phosphatase
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS