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FLASH GENE
Symbol PGBD3 contributors: mct - updated : 29-03-2021
HGNC name piggyBac transposable element derived 3
HGNC id 19400
DNA
TYPE functioning gene
SPECIAL FEATURE overlapping
text
  • overlapping with the ERCC6 gene
  • PGBD3 piggyBac transposon inserted into ERCC6 intron 5 early in the primate lineage
  • STRUCTURE 9.18 kb     24 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2266 - 593 - 2012 23028371
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Urinarybladder    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    cytochrome c heme binding site
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    basic FUNCTION
  • transposase activity
  • ERCC6-PGBD3 fusion protein, like many other proteins that can cause POF, modulates or participates in DNA repair
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ERCC6-PGBD3 fusion protein is important in both health and disease, and could play a role in Cockayne syndrome
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS