basic FUNCTION
| may function as a transcriptional co-repressor |
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incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layer of epidermis, suggesting a role in epithelial cell differentiation and a contribution in epidermal integrity |
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substrate of transglutaminase, involved in the cornification process |
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retards cell cycle progression mainly at the S-phase in part by transcriptionally repressing expression of CDC7, the key regulator of DNA replication, and in part by unknown mechanisms ( |
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involved in multiple cellular functions, and the protein is broadly expressed during embryogenesis and in the adult brain |
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displays an antiapoptotic function by reducing caspase-3 activity |