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FLASH GENE
Symbol DIRAS2 contributors: - updated : 12-03-2004
HGNC name DIRAS family, GTP-binding RAS-like 2
HGNC id 19323
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     0 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC158046 9q22.2 similar to hypothetical protein BC014127 EDG3 9q22.1-q22.2 endothelial differentiation, sphingolipid G-protein-coupled receptor, 3 SHC3 9q22.1 src homology 2 domain containing transforming protein C3 CKS2 9q22 CDC28 protein kinase regulatory subunit 2 SBP2 9q22.2 SECIS binding protein 2 GADD45G 9q22.1-q22.2 growth arrest and DNA-damage-inducible, gamma LOC389770 9 similar to QCWQ6494 LOC389771 9 LOC389771 LOC157916 9q22.31 interleukin 6 receptor pseudogene LOC392365 9 similar to putative taste receptor HTR2 LOC392366 9 similar to seven transmembrane helix receptor DIRAS2 9q22.32 DIRAS family, GTP-binding RAS-like 2 LOC392367 9 similar to putative taste receptor HTR2 LOC283493 9q22.31 similar to seven transmembrane helix receptor SYK 9q22.1-q22.3 spleen tyrosine kinase AUH 9q22 AU RNA binding protein/enoyl-Coenzyme A hydratase NFIL3 9q22 nuclear factor, interleukin 3 regulated ROR2 9q22.3 receptor tyrosine kinase-like orphan receptor 2 LOC347318 9q22.31 similar to 60S ribosomal protein L21 SPTLC1 9q22.1-q22.2 serine palmitoyltransferase, long chain base subunit 1 LOC389772 9 similar to Osteotesticular phosphatase; protein tyrosine phosphatase, receptor type, V LOC392368 9 similar to KIAA1553 protein LOC138652 9q22.32 similar to bA62C3.1 (similar to testicular serine protease) IARS 9q21 isoleucine-tRNA synthetase C9orf34 9q22.32 chromosome 9 open reading frame 34 OGN 9q22.3 osteoglycin (osteoinductive factor, mimecan) OMD 9p22.3 osteomodulin ASPN 9q22-q31 asporin (LRR class 1) ECM2 9q22.3 extracellular matrix protein 2, female organ and adipocyte specific C9orf12 9q21.33-q22.31 chromosome 9 open reading frame 12 BICD2 9q22.1-q22.3 chromosome 9 open reading frame 12
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral lobefrontalhighly
 brainhindbraincerebellumcerebellar cortexhighly
 brainforebraincerebral lobeoccipitalhighly
 brainhindbraincerebellum highly
 brainforebraincerebral lobetemporalhighly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
GTP-binding domain, an effector domain and a C terminal prenylation motif
HOMOLOGY
interspecies homolog to C.elegans C54A12.4
homolog to D.melanogaster CG8500
intraspecies homolog to DIRAS1
homolog to ARHI
Homologene
FAMILY Ras subfamily of Ras small GTPases
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • low level of GTPase activity
  • might regulate cell morphogenesis in a manner distinct from other Ras proteins
  • might function as a growth suppressor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    DIRAS2 exists predominantly as a GTP-bound form
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS