basic FUNCTION
| modulating substrate selectivity and catalytic activity |
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directing the localization of the catalytic enzyme to a particular subcellular compartment |
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regulatory subunit of protein phosphatase 2A consisting of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit c) and a 65 kDa constant regulatory subunit (p65 or subunit a), and associating with a variety of regulatory subunits (including three families of subunits b...) |
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important role in tumorigenesis |
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its activity is required for efficient cardiomyocyte maturation and survival |
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is a negative regulator of NFKB1 in TCR signaling |
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KIF4A and PPP2R5C and PPP2R5E therefore create a spatially restricted negative feedback loop counteracting AURKB in anaphase |
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regulatory subunit of PP2A, and is a novel modulator of liver metabolism in postprandial physiology |
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hepatic PPP2R5C represents an important factor in the functional wiring of energy metabolism and the maintenance of a metabolically healthy state |