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FLASH GENE
Symbol IFNL3 contributors: mct - updated : 30-05-2013
HGNC name interferon, lambda 3
HGNC id 18365
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text component of a cluster of three related cytokine genes (IL28A, IL28B, IL29)
STRUCTURE 1.00 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
intraspecies paralog to IL28A and IL29
Homologene
FAMILY a cytokine related to type I interferons and IL-10 families
CATEGORY signaling cytokine
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • play a critical role in response to microbial challenge and activate the JAK/STAT signaling pathway
  • IFNL1, IFNL2, IFNL3, IL28RA are induced by viruses and mediate antiviral activity, but type III IFNs have an important, specific functional niche at the immune/epithelial interface, as well as in the regulation of Th2 cytokines
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with a heterodimeric class II cytokine receptor (IL10RB-IL28RA)
    cell & other
    REGULATION
    induced by viral infection
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS