basic FUNCTION
| contributes to the dynamic balance between fusion and fission that determines mitochondria morphology |
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GTPase activity |
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crucial for mitochondrial docking and fusion |
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outer mitochondrial membrane protein involved in regulating mitochondrial dynamics |
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role for mitofusins in directly regulating mitochondrial transport and offer important insight into the cell type specificity and molecular mechanisms of axonal degeneration in CMT2A and dominant optic atrophy |
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prevents endonuclease G release from mitochondria and the consequent DNA fragmentation |
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ubiquitination of MFN1 and MFN2 play a role in PINK1/PARK2-mediated mitophagy |
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MFN1 and MFN2 function to maintain mitochondrial networks by binding one another and initiating outer mitochondrial membrane fusion |
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mitochondrial dynamics, particularly those mediated by the mitofusins, play a role in endothelial cell function and viability |
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potential role in regulating the activation of BAX on the outer mitochondrial membrane in a GTPase-dependent manner |
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MFN1, MFN2, PARK2 regulating mitochondrial spheroid formation and mitophagy that could represent different strategies of mitochondrial homeostatic response to oxidative stress |
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novel role for the ER-associated AMFR ubiquitin ligase and the MFN1 mitochondrial fusion factor in mitophagy |