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FLASH GENE
Symbol CD207 contributors: npt/shn - updated : 18-02-2012
HGNC name CD207 molecule, langerin
HGNC id 17935
DNA
TYPE functioning gene
STRUCTURE 5.61 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
Map pter - D2S292 - D2S443 - CD207 - D2S291 - D2S2977 - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1999 - 328 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Respiratorylung    
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningcorneal epithelium   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticepidermal dendritic cell
cell lineage
  • Langerhans cells (
  • dendritic cells CD11c(+)
  • cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an hydrophobic signal anchor
  • a calcium dependant lectin domain
  • a glu-pro-asn motif featuring a single carbohydrate recognition domain (CRD)
  • a proline rich potential signal transduction motif (WPREPPP) and two potential N-glycosylation sites
  • HOMOLOGY
    interspecies ortholog to Cd207, Mus musculus
    ortholog to CD207, Pan troglodytes
    ortholog to Cd207, Rattus norvegicus
    Homologene
    FAMILY Ca2+ dependant (C-type) lectin family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle
    text localized in the Birbeck granules
    basic FUNCTION
  • receptor with a mannose binding specificity, leading to internalization of antigen
  • induces the formation of Birbeck granules
  • could function as an attachment factor for the HIV proteins
  • natural barrier to HIV-1 infection (
  • type II lectin with mannose specificity expressed by Langerhans cells, in epidermis and epithelia
  • cargo molecule that traffics through RAB11A-positive membrane domains of the endosomal recycling pathway (pMID: 22420646)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MYO5B/RAB11A/RAB11FIP2 platform is spatially involved in the regulation of CD207 trafficking at two distinct sites within live cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other down-regulated during Langerhans cells maturation
    up-regulated by TGF-beta
    ASSOCIATED DISORDERS
    corresponding disease(s) BBGRD
    Susceptibility to infection
    Variant & Polymorphism other certain haplotypes may differ in their binding to pathogens and thus might be associated with susceptibility to infection
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS