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FLASH GENE
Symbol PLA1A contributors: mct - updated : 13-06-2007
HGNC name phospholipase A1 member A
HGNC id 17661
DNA
TYPE functioning gene
STRUCTURE 38.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 pharynx   highly
Endocrineparathyroid   highly
Reproductivemale systemprostate   
cell lineage
cell lines melanoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Pla1a
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
text extracellular PLA1s include phosphatidylserine (PS)-specific PLA1 (PS-PLA1)(Aoki 2007)
basic FUNCTION
  • involved in phosphatidylserine metabolism
  • acting specifically on phosphatidylserine (ps) and lyso-ps to hydrolyze fatty acids at the sn-1 position of these phospholipids
  • having a role in the production of lysophospholipid mediators
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS