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FLASH GENE
Symbol LMAN2 contributors: mct - updated : 12-02-2019
HGNC name lectin, mannose-binding 2
HGNC id 16986
DNA
TYPE functioning gene
STRUCTURE 20.32 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1853 - 356 - 2008 18025080
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
 liver   highly
 pancreas exocrine    
Reproductivefemale systemovary   
 female systemuteruscervix  
Skin/Tegumentskin    
Urinarykidney   highly
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal sequence
  • one leguminous lectin-like domain, in its extracellular region
  • a lectin-type carbohydrate recognition domain
  • a C-terminal transmembrane domain, wirh tetrapeptide KRFY
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to rattus Lman2_predicted
    ortholog to murine Lman2
    intraspecies homolog to LMAN2L
    Homologene
    FAMILY family of leguminous type (L-type) lectins
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • type 1 membrane protein
  • localizes to the Golgi apparatus and cycles early in the secretory pathway
  • localizes mainly to the ER and Golgi
  • basic FUNCTION
  • play a role as an intracellular lectin in the early secretory pathway
  • may retrieve misfolded glycoproteins back to the ER that have inadvertently escaped quality control in the ER
  • intracellular lectin that cycles between the endoplasmic reticulum (ER) and the Golgi apparatus, and is thought to act as a cargo receptor in the transport and sorting of glycoprotein
  • new role in the quality control of secretory proteins
  • shedding target and plays a role in phagocytosis in a shedding-dependent manner
  • regulates multiple steps of intracellular transport, including retrograde transport of immature glycoproteins from the Golgi to ER and phagocytosis of pathogens from the extracellular space to the endosome
  • LMAN2, LMAN2L, LMAN1, participate in the vectorial transport of glycoproteins via sugar-protein interactions
  • appears to be specifically required for the accumulation of GPRC5B in the Golgi complex and restriction of GPRC5B transport along the exosomal pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
  • Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively
  • a component
  • LMAN2/SERPINA1 complex localized to Golgi and endoplasmic reticulum (ER)
  • INTERACTION
    DNA
    RNA
    small molecule cofactor, other,
  • two Ca2+ binding
  • interacts with N-acetyl D-galactosamine and high-mannose type glycans
  • protein
  • interaction between LMAN2 and HSPA5, that is carbohydrate-independent
  • bound exclusively to the high-mannose form of SERPINA1 (function of LMAN2 in post-ER quality control of SERPINA1)
  • ADAM17 participates at least in part in the shedding of LMAN2
  • GUCY2C is the first identified receptor client of the lectin chaperone vesicular integral membrane protein, LMAN2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    tuberculosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene low expression of heterozygote genotype A/0 may be associated with protection against tuberculosis
    Marker
    Therapy target
    ANIMAL & CELL MODELS