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FLASH GENE

Symbol

LMAN2

contributors: mct - updated : 12-02-2019

HGNC name	lectin, mannose-binding 2
HGNC id	16986

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	20.32 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006816 8 - 1853 NP_006807 - 356 - 2008 18025080

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       intestine small intestine         liver       highly   pancreas exocrine         Reproductive female system ovary         female system uterus cervix     Skin/Tegument skin         Urinary kidney       highly Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal signal sequence
	one leguminous lectin-like domain, in its extracellular region
	a lectin-type carbohydrate recognition domain
	a C-terminal transmembrane domain, wirh tetrapeptide KRFY

conjugated

GlycoP

isoforms

Precursor

HOMOLOGY

interspecies	ortholog to rattus Lman2_predicted
	ortholog to murine Lman2

intraspecies

homolog to LMAN2L

Homologene

FAMILY

family of leguminous type (L-type) lectins

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
text	type 1 membrane protein
	localizes to the Golgi apparatus and cycles early in the secretory pathway
	localizes mainly to the ER and Golgi

basic FUNCTION	play a role as an intracellular lectin in the early secretory pathway
	may retrieve misfolded glycoproteins back to the ER that have inadvertently escaped quality control in the ER
	intracellular lectin that cycles between the endoplasmic reticulum (ER) and the Golgi apparatus, and is thought to act as a cargo receptor in the transport and sorting of glycoprotein
	new role in the quality control of secretory proteins
	shedding target and plays a role in phagocytosis in a shedding-dependent manner
	regulates multiple steps of intracellular transport, including retrograde transport of immature glycoproteins from the Golgi to ER and phagocytosis of pathogens from the extracellular space to the endosome
	LMAN2, LMAN2L, LMAN1, participate in the vectorial transport of glycoproteins via sugar-protein interactions
	appears to be specifically required for the accumulation of GPRC5B in the Golgi complex and restriction of GPRC5B transport along the exosomal pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively

a component

LMAN2/SERPINA1 complex localized to Golgi and endoplasmic reticulum (ER)

INTERACTION

DNA

RNA

small molecule	cofactor, other,
	two Ca2+ binding
	interacts with N-acetyl D-galactosamine and high-mannose type glycans

protein	interaction between LMAN2 and HSPA5, that is carbohydrate-independent
	bound exclusively to the high-mannose form of SERPINA1 (function of LMAN2 in post-ER quality control of SERPINA1)
	ADAM17 participates at least in part in the shedding of LMAN2
	GUCY2C is the first identified receptor client of the lectin chaperone vesicular integral membrane protein, LMAN2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         tuberculosis

Susceptibility

Variant & Polymorphism

Candidate gene	low expression of heterozygote genotype A/0 may be associated with protection against tuberculosis
Marker
Therapy target

ANIMAL & CELL MODELS