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FLASH GENE
Symbol ERN2 contributors: SGE/npt - updated : 22/10/2008
HGNC name endoplasmic reticulum to nucleus signaling 2
HGNC id 16942
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation, tail to tail
text located 55bp from PLK
STRUCTURE 23.20 kb     22 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 - 3634 107.1 974 - Wang (1998)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
 mouth   highly
 stomach   moderately
Respiratoryrespiratory tracttrachea  predominantly
Urinarybladder   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 34 aa signal peptide
  • a kinase domain activated by trans-autophosphorylation
  • a KEN domain
  • a protein kinase domain
  • HOMOLOGY
    interspecies homolog to rattus Ern2 (82.0 pc)
    homolog to murine Ern2 (82.8 pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text single-pass type I membrane protein
    basic FUNCTION
  • activating the endogenous ER chaperones
  • inducing translational repression through 28S ribosomal RNA cleavage in response to ER stress
  • having a pro-apoptotic activity
  • kinase activity required for activation of the endoribonuclease domain
  • acting as an endonuclease that producing 5'-phosphomonoesters
  • mediating a partial translational attenuation of XBP1 (Imagawa 2008)
  • CELLULAR PROCESS cell cycle
    cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text
  • induction of apoptosis
  • negative regulation of transcription
  • cell cycle arrest
  • PATHWAY
    metabolism nucleic
    signaling
    rRNA catabolic process
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Mg2+
  • ATP
  • protein
  • NR2F1 and ERN2 suppress MTTP expression and lipoprotein assembly in undifferentiated intestinal epithelial cell
  • cell & other
    REGULATION
    Other autophosphorylated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS