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FLASH GENE
Symbol IGSF11 contributors: - updated : 15-02-2006
HGNC name immunoglobulin superfamily, member 11
HGNC id 16669
DNA
TYPE functioning gene
STRUCTURE 212.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3446 46 431 - Harada
  • differs in the 5' UTR
  • has a distinct N-terminus
  • - - 3577 46 430 - Harada
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   lowly
    Nervousbrainlimbic systemhippocampusdentate gyruslowly
     brainbasal nucleicorpus callosum lowly
    Reproductivemale systemtestis  highly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • three extracellular N-linked glycosylation sites
  • a V-type Ig-like domain
  • a C2-type Ig-like domain
  • a C-terminal PDZ-interacting motif
  • mono polymer monomer
    HOMOLOGY
    interspecies ortholog to rattus Igsf11_predicted
    ortholog to murine Igsf11
    intraspecies homolog to CXADR
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may play a role in the development or function of the central nervous system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    frequently, in intestinal-type gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene good candidate of cancer-testis antigen
    Marker
    Therapy target target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas
    ANIMAL & CELL MODELS