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FLASH GENE
Symbol STK35 contributors: - updated : 26-10-2004
HGNC name serine/threonine kinase 35
HGNC id 16254
DNA
TYPE functioning gene
STRUCTURE 45.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Authors GeneMap (99)
regionally located between D20S117 and D20S113
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a serine/threonine kinase domain
  • four potential NLS signals
  • a proline-rich region
  • HOMOLOGY
    interspecies homolog to murine 1700054C12Rik
    homolog to rattus LOC311419
    Homologene
    FAMILY
  • protein kinase superfamily
  • ser/thr protein kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text predominantly nuclear but relocalized to actin stress fibers under PDLIM1 association
    basic FUNCTION
  • protein serine/threonine kinase activity
  • may be a regulator of actin stress fibers in non muscle cells
  • involved in autophagy
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • can interact with PDLIM1/CLP-36 in the cytoplasm
  • cell & other
    REGULATION
    Other autophosphorylated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS