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FLASH GENE
Symbol MUC15 contributors: - updated : 15-04-2004
HGNC name mucin 15
HGNC id 14956
DNA
TYPE functioning gene
STRUCTURE 12.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
 thymus    
Digestiveintestinelarge intestinecolon  
 intestinesmall intestine   
 intestinelarge intestine   
Hearing/Equilibriumearinnercochlea  
Lymphoid/Immunetonsils    
Reproductivefemale systembreast   
 female systembreastmammary gland  
 female systemovary   
 male systemprostate   
 male systemtestis   
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Respiratoryepithelial cell
cell lineage
cell lines
fluid/secretion milk
at STAGE
physiological period fetal, pregnancy
Text placenta, liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal peptide signal
  • an extracellular N-terminal region rich in ser, thr, pro, leu, and asn residues
  • a transmembrane domain
  • containing numerous potential glycosylation sites (O and N types)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to bovine Muc15
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • required to mediate mannosylphosphate transfer in both the core and outer chain portions of N-linked oligosaccharides
  • provides a physical barrier protecting the underlying epithelium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS