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FLASH GENE

Symbol

PPP1R2

contributors: mct - updated : 21-09-2012

HGNC name	protein phosphatase 1, regulatory (inhibitor) subunit 2
HGNC id	9288

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	29.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006241 6 - 3475 NP_006232 - 205 - 2008 19036150

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       highly Reproductive female system breast mammary gland   highly Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to murine Ppp1r2
	homolog to C.elegans Y32H12A.4

intraspecies

homolog to IPP-2

Homologene

FAMILY

protein phosphatase inhibitor 2 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule
text	found concentrated in cilia of epithelial cells, and was localized to cilia early in the process of formation, prior to the full acetylation of microtubules

basic FUNCTION	inhibitor subunit of protein phosphatase 1, involved in mammalian cell division
	acts to enhance Aurora B by inhibiting specific PPP1CA holoenzymes that dephosphorylate Aurora B substrates necessary for chromosome segregation and cytokinesis
	localizes to the primary cilium where it affects both Ser/Thr phosphorylation and is required for full tubulin acetylation
	as a multifunctional protein, may link cell cycle progression to structure and stability of the primary cilium
	major serine/threonine-phosphatase whose activity is dependent on its binding to regulatory subunits known as PP1 interacting proteins (PIPs), responsible for targeting PP1 to a specific cellular location, specifying its substrate or regulating its action

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

energy pathways

a component

INTERACTION

DNA

RNA

small molecule

protein

catalytic subunit of PP1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal, lung, gastric ovarian carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS