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FLASH GENE
Symbol LYL1 contributors: mct - updated : 31-08-2010
HGNC name lymphoblastic leukemia derived sequence 1
HGNC id 6734
DNA
TYPE functioning gene
STRUCTURE 3.83 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure promoter region revealed potential binding sites for transcription factors HOXA10, LMO2 and NKX2-5 (Nagel 2010)
MAPPING cloned Y linked   status confirmed
Map pter - D19S461 /D19S413 - D19S535 - (ICAM1 - LDLR LDLR ) - JUNB - LYL1 /D19S817 - D19S171 - D19S411 - cen
Authors Collin (96)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1788 29.81 280 - San-Marina (2008)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbrainmedulla oblongata  
Respiratorylung    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic helix-loop-helix (HLH) protein
  • HOMOLOGY
    Homologene
    FAMILY
  • BHLH family
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in DNA binding throught dimerization with another BHLH protein
  • required for fetal and adult hematopoietic stem cell function and B-cell differentiation (Capron 2006)
  • controls the expression of molecules involved in the stabilization of vascular structuresand plays a role for in the postnatal maturation of newly formed blood vessels (Pirot 2010)
  • important for B cell development (Souroullas 2009)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • with BHLH proteins
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • CREB1 binding partner for LYL1 but not for TAL1 (interaction between LYL1 and CREB1 involves the N terminal domain of LYL1 and the Q2 and KID domains of CREB1) (San Marina 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation --low  
    t(7;19)(q35;p13) in T cell leukemia with worse response to treatment
    tumoral     --other  
    with TAL1, aberrantly over-expressed in leukemia as a result of chromosomal translocations (San-Marina 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Lyl-1 null mice are viable and display normal blood cell counts, except for a reduced number of B cells resulting from a partial block after the pro-B stage (Capron 2006)