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FLASH GENE
Symbol CCR5 contributors: mct - updated : 07-07-2010
HGNC name chemokine (C-C motif) receptor 5
HGNC id 1606
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text member of a chemokine receptor gene cluster
STRUCTURE 6.06 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
CCR2 3p21.31 chemokine (C-C motif) receptor 2 CCR5 3p21.31 chemokine (C-C motif) receptor 5 CCRL2 3p21.32-p21.31 chemokine (C-C motif) receptor-like 2 CHL1 3p26 cell adhesion molecule with homology to L1CAM (close homolog of L1) LOC391503 3 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) CNTN6 3p26-p25 contactin 6 LOC391504 3 similar to 60S ribosomal protein L23a LOC391505 3 similar to 60S ribosomal protein L21 CNTN4 3p26.2 contactin 4 IL5RA 3p26-p25 interleukin 5 receptor, alpha TRNT1 3p25.1 tRNA nucleotidyl transferase, CCA-adding, 1 LOC51185 3p26.2 protein x 0001 LRRN1 3p26.2 leucine rich repeat neuronal 1 SETMAR 3p26.1 SET domain and mariner transposase fusion gene SUMF1 3p26.2 SET domain and mariner transposase fusion gene MRPS10P2 3p26 mitochondrial ribosomal protein S10 pseudogene 2 ITPR1 3p26-p25 inositol 1,4,5-triphosphate receptor, type 1 BHLHB2 3p26.1-p25.3 basic helix-loop-helix domain containing, class B, 2 LOC391506 3 similar to autoantigen NOR-90 FLJ10702 EDEM1 3p26.1 ER degradation enhancer, mannosidase alpha-like 1 MRPS35P1 3p25.3 mitochondrial ribosomal protein S35 pseudogene 1 MRPS36P1 3p25.3 mitochondrial ribosomal protein S36 pseudogene GRM7 3p26.1-p25.2 glutamate receptor, metabotropic 7 LOC389092 3 LOC389092 LMCD1 3p26-p24 LIM and cysteine-rich domains 1 LOH3CR2A 3 loss of heterozygosity, 3, chromosomal region 2, gene A LOC51066 3p25.3 fls485 LOC391507 3 similar to seven transmembrane helix receptor CAV3 3p25 caveolin 3 OXTR 3p25 oxytocin receptor RAD18 3p25-p24 RAD18 homolog (S. cerevisiae)
RNA
TRANSCRIPTS type messenger
text differing in their 5'utr by alternative splicing of exon 2 and exon 3
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 initiation site 3686 40.5 352 lymphocytes - 8663314
3 initiation site 3451 62 352 - - 8663314
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 thymus    
Urinarykidney    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines promyeloblastic cell line
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five transmembrane domains (TM3-TM6) sufficient for the function
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • mediating macrophage-tropic strains of HIV-1 entry in CD4+ T lymphocytes
  • during human T cell activation by antigen-presenting cells, recruited into the immunological synapse, where they deliver costimulatory signals
  • important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction
  • CXCR4 and the related CCR5 serve as co-receptors for HIV-1 viral particles, facilitating their entry into cells
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS immunity/defense
    text granulocyte
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
  • DARC hetero-oligomerizes with the CC chemokine receptor CCR5 (DARC-CCR5 interaction impairs chemotaxis and calcium flux through CCR5)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PRAF2
  • interaction between CXCR4 and CCR5 to exert specific biological functions and modulate T lymphocyte responses, and cooperation between receptors represents one key strategy for the functional plasticity of chemokines
  • interacting with TPST2 (involved in tyrosine sulfation of CCR5 N-terminal peptide)
  • interacting with arrestins (arrestins may serve as scaffolding proteins linking CCR5 to multiple downstream signaling molecules in a biologically important primary cell type)
  • cell & other
    REGULATION
    activated by IL-10 (associated with increased migration of microglia in response to macrophage inflammatory protein-1 beta)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to AIDS lymphoma
  • to HIV disease progression, resistance or non progressive infections
  • to West Nile virus (Omim 610379)
  • to juvenile idiopathic arthritis (JIA)
  • Variant & Polymorphism other
  • reduced risk of AIDS lymphoma with the CCR5-delta 32 mutation
  • CCR5Delta32 is a functional variant, significantly associated with protection from developing JIA
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS