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FLASH GENE

Symbol

TFEC

contributors: mct - updated : 03-09-2013

HGNC name	transcription factor EC
HGNC id	11754

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	224.75 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001018058 7 - 6613 NP_001018068 - 318 - 2001 11467950 NM_012252 8 - 6700 NP_036384 - 347 - 2001 11467950 NM_001244583 6 - 6309 NP_001231512 - 280 - 2001 11467950

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage
cell lines	monocytic leukemia cell line
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a basic helix-loop-helix (bHLH) domain
	a lecuine zipper domain

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to murine Tcfec
	homolog to rattus Tfec

intraspecies

paralog to MITF

Homologene

FAMILY

MItf-Tfe family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	can activate or inhibit promoters of melanocyte-specific tyrosinase and the heme oxygenase-1 gene (HMOX1) depending on cell type
	sequence-specific transcriptional activator of the non muscle myosin heavy chain A gene

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding a CANNTG motif (E box)

RNA

small molecule

protein	TFE3 and TFEC proteins may collaborate with MITF to efficiently regulate expression of target genes in osteoclasts
	in conjunction with MITF/TFEC, PAX6 acts as an anti-retinogenic factor, whereas in conjunction with retinogenic genes it acts as a pro-retinogenic factor

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS