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FLASH GENE
Symbol HSPH1 contributors: mct/npt - updated : 19-10-2015
HGNC name heat shock 105kDa/110kDa protein 1
HGNC id 16969
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 28.14 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 5360 96 858 . expressed constitutively and is further induced under stress conditions . is localized mainly in the cytoplasm 2008 18681888
  • HSP105 alpha
  • has opposite effects on stress-induced apoptosis depending on the cell type
  • 17 - 5228 - 814 . is only expressed during mild heat shock . is localized in the nucleus 2008 18681888
  • HSP105 beta
  • NMI is an Hsp105 beta-binding protein
  • 16 - 4987 - 782 - 2008 18681888
    18 - 5221 - 860 - 2008 18681888
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Nervousbrainforebraincerebral lobefrontal 
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningepidermis  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Nervousglia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text amnion cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • subgroup of the HSP70 family, HSP105/110
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • having ATP binding activity
  • suppress H2O2-induced apoptosis by suppression of p38 MAPK signaling, one of the essential pathways for apoptosis
  • thought to be a more relevant tumor-associated antigen in malignant melanoma than is HSPA5 (Park 2009)
  • may play an important role in the refolding of denatured proteins and protection against stress-induced cell death in mammalian cells
  • important element of the Hsp70 chaperone machinery for refolding of denatured proteins and protection against stress-induced cell death in mammalian cells
  • has a primary role promoting CFTR quality control at an earlier stage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with glycogen synthase kinase-3 (GSK3B), a promoter of ER stress-induced apoptosis, and HSPA5, a key component of the unfolded protein response (promotes ER stress-induced caspase-3 activation)(Meares 2008)
  • HSPH1 suppressed the expanded polyQ tract-induced protein aggregation and apoptosis through the induction of HSPA4
  • HSPH1 is required for WNT signaling, since depletion of HSPH1 compromises CTNNB1 accumulation and target gene transcription upon WNT stimulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon and pancreatic adenocarcinoma
    tumoral     --over  
    in skin cancers including extramammary Paget disease (EMPD), and cutaneous squamous cell carcinoma (SCC)
    tumoral     --over  
    in melanoma cell lines (Muchemwa 2008)
    tumoral     --over  
    is a prognostic biomarker that correlates with poor overall survival in breast cancer patients as well as melanoma patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS